Why are PKs important?
The polyketides (PKs) are a group of SMs produced by many organisms, including filamentous fungi. Many polyketides are clinically important, with antimicrobial, anticancer and immunosuppressive properties.
What are PKs genes?
Polyketide synthases (PKSs) are a family of multi-domain enzymes or enzyme complexes that produce polyketides, a large class of secondary metabolites, in bacteria, fungi, plants, and a few animal lineages. The biosyntheses of polyketides share striking similarities with fatty acid biosynthesis.
What is PKs pathway?
3 Polyketide biosynthesis pathway. Polyketides are a group of natural products that are synthesized by bacteria, fungi, and plants. They illustrate significant importance in producing medicines and hydrocarbon biofuels. Polyketides are synthesized from acetyl-CoA by polyketide synthases (PKSs).
What are polyketides made of?
Polyketides are a class of natural products derived from a precursor molecule consisting of a chain of alternating ketone (or reduced forms of a ketone) and methylene groups: (-CO-CH2-). First studied in the early 20th century, discovery, biosynthesis, and application of polyketides has evolved.
What is polyketides function?
Polyketides Genes Many polyketides are clinically important, with antimicrobial, anticancer and immunosuppressive properties. Moreover, they are important in the producing organisms, facilitating competition for substrates and communication between organisms (Khosla, 2009).
What do polyketides do?
Polyketides are natural metabolites that comprise the basic chemical structure of various anticancer, antifungal, and anticholesteremic agents; antibiotics; parasiticides and immunomodulators.
What are polyketides used for?
Polyketides are structurally diverse and biologically active secondary metabolites derived from natural sources such as animals, plants, fungi and bacteria [1]. These compounds are widely used as clinical medicines for the treatment of various acute and chronic diseases [2].