What causes bone erosions?
Bone erosion is typically caused by erosive arthritis conditions like PsA and rheumatoid arthritis (RA). Conditions like PsA and RA can progress, which means worsening inflammation, and the more inflammation there is, the more damage there will be to the bones.
What causes bone erosion in the wrist?
The main triggers of articular bone erosion are synovitis, including the production of proinflammatory cytokines and receptor activator of nuclear factor κB ligand (RANKL), as well as antibodies directed against citrullinated proteins.
How serious is bone erosion?
This progressive disease not only causes joint inflammation, but can lead to damage and deformity of joints. The damage is a result of erosion of the bones. Bone erosion is a key feature of RA. The risk increases with disease severity and is characterized by the loss of bone in certain parts of the body.
What does joint erosion mean?
Bone erosion is the loss of bone from disease processes. Erosive arthritis is joint inflammation (arthritis) with bone destruction, and such conditions include rheumatoid arthritis. Bone erosion is the loss of bone in a certain area, rather than a change in bone density, which is found in osteoporosis.
Are bone erosions painful?
traditional osteoarthritis. Erosive osteoarthritis tends to produce more pain, swelling, and functional disability in an affected joint than traditional osteoarthritis. It also involves the erosion or destruction of bone.
What does bone erosion feel like?
In erosive OA, however, imaging shows areas of bone damage (erosions) that start in the central part of the bone and create deformities with a distinctive shape. The condition is sometimes also called inflammatory OA because there are also signs of inflammation such as swelling, redness, and warmth of the joints.
How long does bone erosion take?
More than 10% of the patients develop bone erosions within 8 weeks after disease onset, while up to 60% have erosions after 1 year[2]. Bone erosions progress in time and contribute to joint damage in patients with RA, leading to impaired functional capacity[3,4].