What are Lymphoplasmacytic cells?
Lymphoplasmacytic lymphoma gets its name because the lymphoma cells have characteristics of both lymphocytes and plasma cells. It is an uncommon type of B-cell non-Hodgkin lymphoma (NHL). Lymphoplasmacytic lymphoma usually occurs in older adults. The average age at diagnosis is 60.
What is the difference between Waldenstrom’s macroglobulinemia and multiple myeloma?
Multiple myeloma represents a malignant proliferation of plasma cells derived from a single clone within the bone marrow. While the cause of myeloma is not known, interleukin 6 may play a role in driving myeloma cell proliferation. Waldenstrom’s macroglobulinemia (WM) is a proliferative disease of B-lymphocytes.
What are the symptoms of Waldenstrom macroglobulinemia?
Symptoms can include heart palpitations, feeling tired and weak, cough, shortness of breath, rapid weight gain, and swelling in the feet and legs. Infections: The high levels of abnormal antibody in WM can slow the body’s normal antibody production. This makes it harder for the body to fight infections.
What is Waldenstrom syndrome?
Waldenstrom macroglobulinemia (mak-roe-glob-u-lih-NEE-me-uh) is a rare type of cancer that begins in the white blood cells. If you have Waldenstrom macroglobulinemia, your bone marrow produces too many abnormal white blood cells that crowd out healthy blood cells.
What causes Lymphoplasmacytic?
Lymphoplasmacytic lymphoma (LPL) is a low-grade (slow-growing) non-Hodgkin lymphoma. It develops from B lymphocytes (a type of white blood cell) that become abnormal and grow out of control. White blood cells form part of your immune system, which helps fight infections.
What is a Lymphoplasmacytic infiltrate?
Lymphoplasmacytic infiltrates in the breast, a modified skin appendage, include lymphocytic lobulitis, other nonspecific benign proliferations, and mucosa-associated lymphoid tissue (MALT)–type lymphoma. Distinguishing these entities, all of which may be B-cell rich and may have associated sclerosis, can be difficult.
What are the end stages of Waldenstrom’s?
Staging/Prognostic Scoring System for Waldenstrom Macroglobulinemia/Lymphoplasmacytic Lymphoma
| Score | Stage | 3-year WM-related mortality |
|---|---|---|
| 1 | Low | 10% |
| 2 | Intermediate | 14% |
| 3 | High | 38% |
| 4-5 | Very high | 48% |
Is Waldenstrom leukemia?
For additional information about WM, please see the free Leukemia & Lymphoma Society (LLS) booklet Non-Hodgkin Lymphoma. Waldenström macroglobulinemia (WM), also called “lymphoplasmacytic lymphoma,” is a rare, indolent (slow-growing) blood cancer that is treatable with available therapies but is not curable.
What causes WM?
What causes Waldenstrom macroglobulinemia (WM)? Doctors do not know what causes WM but believe it involves a gene mutation. Recent research has found that WM cells have a mutation (change) in a gene known as MYD88, which normally helps immune system cells signal each other and helps keep them alive.
What is the treatment for Lymphoplasmacytic lymphoma?
Symptomatic patients are managed by chemotherapy, immunotherapy, and/or an autologous bone marrow stem cell transplant. Chemotherapeutic agents that are effective in managing Waldenstrom macroglobulinemia include dexamethasone, fludarabine, bortezomib, and cyclophosphamide.