What is vincristine neuropathy?

Vincristine-induced motor neuropathy is characterized by weakness in the upper and lower extremities and the development of wrist- or foot-drop due to impaired dorsiflexion that arises from damage to peripheral nerves.

How is vincristine-induced neuropathy treated?

Regarding interventions for established CIPN, duloxetine is the only drug with demonstrated efficacy for paclitaxel-or oxaliplatin-induced painful CIPN [82]. Specifically, agents such as venlafaxine, amifostine, glutamine, amitriptyline, Org 2766, electrolytes and vitamins were studied for CIPN prevention.

Is vincristine neuropathy reversible?

Vincristine neuropathy is usually reversible when therapy is discontinued. The median duration of paresthesias and motor weakness after treatment discontinuation is 3 months. Cramps in small hand but in particular small foot muscles occur.

Does vincristine cause neurotoxicity?

Vincristine is an antineoplastic drug with a broad spectrum of activity against haematological malignancies and childhood sarcomas. Besides useful activity, it lacks the usual emetic and myelotoxicity of anticancer drugs, but its use is limited by neurotoxicity.

What are the side effects of vincristine?

More common

  • Blurred or double vision.
  • difficulty in walking.
  • drooping eyelids.
  • headache.
  • jaw pain.
  • numbness or tingling in fingers and toes.
  • pain in fingers and toes.
  • pain in testicles.

What are the long term side effects of vincristine?

With continued treatment, neuritic pain and later, motor difficulties may occur. Loss of deep-tendon reflexes, foot drop, wrist drop, ataxia, and paralysis have been reported with continued administration.

How long does neuropathy last after chemo?

Chemo-induced neuropathy symptoms are usually the worst 3-5 months after the last chemotherapy dose. After that, symptoms may disappear completely, lessen, or affect less of the body; if symptoms disappear or diminish, that occurs gradually, usually over several months.

Which type of kidney damage is related to the adverse effects of chemotherapy?

Multiple chemotherapy regimens have been associated with interstitial nephritis, most notably ipilimumab. In ipilimumab-induced interstitial nephritis, patients are treated with prednisone and quickly return to their baseline kidney function [7].

Why is vincristine being discontinued?

Teva discontinued production of the medication in early June 2019, leaving Pfizer as the sole supplier. Since then, manufacturing delays and increased demand have resulted in shortages of the drug, causing considerable concern within the pediatric patient community.

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