What is BCL6 gene?
BCL6 (BCL6 Transcription Repressor) is a Protein Coding gene. Diseases associated with BCL6 include Primary Mediastinal Large B-Cell Lymphoma and Intravascular Large B-Cell Lymphoma. Among its related pathways are Signaling events mediated by HDAC Class II and Cytokine Signaling in Immune system.
What does the Jun gene do?
The human JUN encodes a protein that is highly similar to the viral protein, which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.
Is Jun An oncogene?
JUN (Jun Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUN include Sarcoma and Primary Cutaneous T-Cell Lymphoma.
What chromosome is BCL6 on?
Introduction. The BCL6 gene on chromosome 3q27 encodes a 96 kDa sequence-specific transcriptional repressor protein with 6 C-terminal zinc-finger motifs and an N-terminal POZ/ZIN domain homologous to a family of zinc-finger proteins.
What does BCL2 positive mean?
The gene for BCL2 is found on chromosome 18, and transfer of the BCL2 gene to a different chromosome is seen in many B-cell leukemias and lymphomas. This causes the BCL2 protein to be made in larger amounts, which may keep cancer cells from dying. Also called B-cell leukemia/lymphoma 2 protein.
Does BCL6 3 exist?
The deletion of BCL6 is known to lead to failure to germinal center formation in the follicles of the lymph nodes, preventing B cells from undergoing somatic hypermutation….
|Location (UCSC)||Chr 3: 187.72 – 187.75 Mb||Chr 16: 23.78 – 23.81 Mb|
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What is BCL6 positive?
Bcl-6 was positive in 13.6% (6 of 44) of cases (11.1% of mantle cell lymphoma and 40% of diffuse large B-cell lymphoma) and its positivity implies a better disease course. Bcl-2 and Bcl-6 can be used as prognostic marker in NHL. Key words: Bcl-2, Bcl-6, Non-Hodgkin’s lymphoma.
Is BCL2 a tumor suppressor gene?
Bcl-2 is widely believed to be an apoptosis suppressor gene. Overexpression of the protein in cancer cells may block or delay onset of apoptosis, by selecting and maintaining long-living cells and arresting cells in the G0 phase of the cell cycle.
How does a leucine zipper interact with DNA?
The Leucine Zipper and the Basic DNA-Binding Domain (bZIP) In turn, such dimerization results in the correct protein structure for DNA binding by the adjacent highly basic region that can interact directly with the acidic DNA.