What is BCL6 gene?

BCL6 (BCL6 Transcription Repressor) is a Protein Coding gene. Diseases associated with BCL6 include Primary Mediastinal Large B-Cell Lymphoma and Intravascular Large B-Cell Lymphoma. Among its related pathways are Signaling events mediated by HDAC Class II and Cytokine Signaling in Immune system.

What does the Jun gene do?

The human JUN encodes a protein that is highly similar to the viral protein, which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.

Is Jun An oncogene?

JUN (Jun Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUN include Sarcoma and Primary Cutaneous T-Cell Lymphoma.

What chromosome is BCL6 on?

chromosome 3q27
Introduction. The BCL6 gene on chromosome 3q27 encodes a 96 kDa sequence-specific transcriptional repressor protein with 6 C-terminal zinc-finger motifs and an N-terminal POZ/ZIN domain homologous to a family of zinc-finger proteins.

What does BCL2 positive mean?

The gene for BCL2 is found on chromosome 18, and transfer of the BCL2 gene to a different chromosome is seen in many B-cell leukemias and lymphomas. This causes the BCL2 protein to be made in larger amounts, which may keep cancer cells from dying. Also called B-cell leukemia/lymphoma 2 protein.

Does BCL6 3 exist?

The deletion of BCL6 is known to lead to failure to germinal center formation in the follicles of the lymph nodes, preventing B cells from undergoing somatic hypermutation….

Location (UCSC) Chr 3: 187.72 – 187.75 Mb Chr 16: 23.78 – 23.81 Mb
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What is BCL6 positive?

Bcl-6 was positive in 13.6% (6 of 44) of cases (11.1% of mantle cell lymphoma and 40% of diffuse large B-cell lymphoma) and its positivity implies a better disease course. Bcl-2 and Bcl-6 can be used as prognostic marker in NHL. Key words: Bcl-2, Bcl-6, Non-Hodgkin’s lymphoma.

Is BCL2 a tumor suppressor gene?

Bcl-2 is widely believed to be an apoptosis suppressor gene. Overexpression of the protein in cancer cells may block or delay onset of apoptosis, by selecting and maintaining long-living cells and arresting cells in the G0 phase of the cell cycle.

How does a leucine zipper interact with DNA?

The Leucine Zipper and the Basic DNA-Binding Domain (bZIP) In turn, such dimerization results in the correct protein structure for DNA binding by the adjacent highly basic region that can interact directly with the acidic DNA.


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