What is BCL6 gene?
BCL6 (BCL6 Transcription Repressor) is a Protein Coding gene. Diseases associated with BCL6 include Primary Mediastinal Large B-Cell Lymphoma and Intravascular Large B-Cell Lymphoma. Among its related pathways are Signaling events mediated by HDAC Class II and Cytokine Signaling in Immune system.
What does the Jun gene do?
The human JUN encodes a protein that is highly similar to the viral protein, which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.
Is Jun An oncogene?
JUN (Jun Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUN include Sarcoma and Primary Cutaneous T-Cell Lymphoma.
What chromosome is BCL6 on?
chromosome 3q27
Introduction. The BCL6 gene on chromosome 3q27 encodes a 96 kDa sequence-specific transcriptional repressor protein with 6 C-terminal zinc-finger motifs and an N-terminal POZ/ZIN domain homologous to a family of zinc-finger proteins.
What does BCL2 positive mean?
The gene for BCL2 is found on chromosome 18, and transfer of the BCL2 gene to a different chromosome is seen in many B-cell leukemias and lymphomas. This causes the BCL2 protein to be made in larger amounts, which may keep cancer cells from dying. Also called B-cell leukemia/lymphoma 2 protein.
Does BCL6 3 exist?
The deletion of BCL6 is known to lead to failure to germinal center formation in the follicles of the lymph nodes, preventing B cells from undergoing somatic hypermutation….
| BCL6 | ||
|---|---|---|
| Location (UCSC) | Chr 3: 187.72 – 187.75 Mb | Chr 16: 23.78 – 23.81 Mb |
| PubMed search | ||
| Wikidata | ||
| View/Edit Human View/Edit Mouse |
What is BCL6 positive?
Bcl-6 was positive in 13.6% (6 of 44) of cases (11.1% of mantle cell lymphoma and 40% of diffuse large B-cell lymphoma) and its positivity implies a better disease course. Bcl-2 and Bcl-6 can be used as prognostic marker in NHL. Key words: Bcl-2, Bcl-6, Non-Hodgkin’s lymphoma.
Is BCL2 a tumor suppressor gene?
Bcl-2 is widely believed to be an apoptosis suppressor gene. Overexpression of the protein in cancer cells may block or delay onset of apoptosis, by selecting and maintaining long-living cells and arresting cells in the G0 phase of the cell cycle.
How does a leucine zipper interact with DNA?
The Leucine Zipper and the Basic DNA-Binding Domain (bZIP) In turn, such dimerization results in the correct protein structure for DNA binding by the adjacent highly basic region that can interact directly with the acidic DNA.
https://www.youtube.com/watch?v=7uF3sydanQk