What causes Phospholipidosis?

Mechanistically, phospholipidosis is caused by cationic amphipathic molecules binding to cellular phospholipids and inhibiting complete digestion by lysosomal phospholipase A1, A2, or C within lysosomes, although, less often, direct inhibition of phospholipase can occur, as in the case of gentamicin.

What cationic amphiphilic?

Cationic amphiphilic drugs (CADs) are a wide group of chemicals that are characterized by common structural features, that is, a hydrophobic aromatic ring or ring system and a hydrophilic side-chain containing an ionizable amine functional group.

What is Pulmonary phospholipidosis?

Chronic administration of amphiphilic drugs to rats induces pulmonary phospholipidosis (P), a disease characterized by accumulation of phospholipids and large foamy macrophages in alveolar spaces. We investigated whether P induced by chlorphentermine (CPH) causes changes in lung volumes and mechanics in this species.

What is an amphiphilic drug?

Amphiphilic drugs are molecular drugs or drug conjugates possessing both hydrophilic and lipophilic properties. Representative amphiphilic drugs are composed of a pharmaceutical payload, a linker, and an appropriate amphiphilic modification.

What does it mean to be amphiphilic?

Definition of amphiphilic : of, relating to, or being a compound (such as a surfactant) consisting of molecules having a polar water-soluble group attached to a water-insoluble hydrocarbon chain also : being a molecule of such a compound.

What is amphiphilic structure?

Amphiphilic molecules is a general term that describes any compound that contains two distinct covalently bonded components with different affinity for the solvent in the same molecule, in which one part possesses a high affinity for polar solvents (such as water), and another part has a strong affinity for nonpolar …

Why surfactants are called amphiphiles?

Surfactants are usually organic compounds that are amphiphilic, meaning they contain both hydrophobic groups (their tails) and hydrophilic groups (their heads).

What are amphiphiles in pharmacy?

Amphiphiles are compounds possessing both hydrophilic (water-loving) and lipophilic (fat-loving) or water-hating components. In conventional head/tail(s) amphiphiles the lipophilic part consists generally of a long (saturated or unsaturated) hydrocarbon chain, while the hydrophilic head can be either nonionic or ionic.

What are amphipathic substances?

Amphipathic molecules are chemical compounds that have both polar and nonpolar regions, giving them both hydrophilic (water-loving) and lipophilic (fat-loving) properties. Amphipathic molecules are also known as amphiphilic molecules or amphiphiles.

What is amphiphilic solvent?

What are amphiphiles in physical pharmaceutics?

Amphiphiles are molecules containing a nonpolar hydrophobic region and a polar hydrophilic region will self-assemble in aqueous solution to form distinct structures such as micelles, vesicles and tubules.

What do amphiphiles do?

Biological role Phospholipids, a class of amphiphilic molecules, are the main components of biological membranes. The amphiphilic nature of these molecules defines the way in which they form membranes. They arrange themselves into lipid bilayers, by forming a sheet composed of two layers of lipids.

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