Do you give cisplatin before etoposide?

Beginning on the first day of radiotherapy, patients receive cisplatin IV over 2 hours and etoposide IV over 1 hour on day 1 and oral etoposide once daily on days 2 and 3. Chemotherapy repeats every 3 weeks for up to 4 courses in the absence of disease progression or unacceptable toxicity.

What is etoposide and cisplatin?

What is etoposide and cisplatin? Etoposide and cisplatin chemotherapy (EP) is a combination chemotherapy treatment used to treat different types of cancer. It is best to read this information with our general information about chemotherapy and the type of cancer you have.

What are the most common side effects of cisplatin and etoposide?

Diarrhea, loss of appetite, nausea, vomiting. Tiredness. Fever, chills.

How often is cisplatin given?

Cisplatin injection comes as a solution (liquid) to be injected over 6 to 8 hours intravenously (into a vein) by a doctor or nurse in a medical facility. It is usually given once every 3 to 4 weeks.

What are the long term side effects of cisplatin chemotherapy?

One of the most common long-term side effects of Platinol (cisplatin), a medication used for many cancers including lung cancer, is ototoxicity (damage to the structures of the ear). Other medications may also cause hearing loss and tinnitus (ringing in the ears).

How does cisplatin work on cancer cells?

Cisplatin binds to the N7 reactive center on purine residues and as such can cause deoxyribonucleic acid (DNA) damage in cancer cells, blocking cell division and resulting in apoptotic cell death. The 1,2-intrastrand cross-links of purine bases with cisplatin are the most notable among the changes in DNA.

Can etoposide cause secondary malignancies?

It has been widely used for the treatment of many types of cancers in children and adults [1]. However, etoposide has been associated with an increased risk of secondary leukemia.

Which cancers are treated with cisplatin?

Cisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and other similar platinum-based drugs were developed with National Cancer Institute (NCI) support.

How long can you stay on cisplatin?

You have chemotherapy as a course of several sessions (or cycles) of treatment over a few months. Each cycle of cisplatin usually takes 21 days (3 weeks). You usually have the cisplatin on the first day of each cycle. But this will depend on the type of cancer you have.

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