What is Mx1 cre?
The Cre recombinase is under the control of the Mx1 promoter. This promoter is silent in healthy mice, but can be induced to high levels of transcription by administration of interferon alpha, interferon beta, or synthetic double-stranded RNA.
What is hematopoietic stem?
(hee-MA-toh-poy-EH-tik stem sel) An immature cell that can develop into all types of blood cells, including white blood cells, red blood cells, and platelets. Hematopoietic stem cells are found in the peripheral blood and the bone marrow. Also called blood stem cell.
What are the two types of hematopoietic stem cells?
Hematopoietic stem cells give rise to different types of blood cells, in lines called myeloid and lymphoid. Myeloid and lymphoid lineages both are involved in dendritic cell formation. Myeloid cells include monocytes, macrophages, neutrophils, basophils, eosinophils, erythrocytes, and megakaryocytes to platelets.
What is the function of a hematopoietic stem cell?
Hematopoietic stem cells (HSCs) are responsible for the production of mature blood cells in bone marrow; peripheral pancytopenia is a common clinical presentation resulting from several different conditions, including hematological or extra-hematological diseases (mostly cancers) affecting the marrow function, as well …
What does Cre recombinase do?
Cre recombinase plays important roles in the life cycle of the P1 bacteriophage. Upon infection of a cell the Cre-loxP system is used to cause circularization of the P1 DNA. In addition to this Cre is also used to resolve dimeric lysogenic P1 DNA that forms during the cell division of the phage.
What are the features of hematopoietic stem cells?
The two critical characteristics of a hematopoietic stem cell are its ability to differentiate into all blood cell types and to self-renew.
What is HSC in immunology?
Hematopoietic stem cells (HSCs) can self-renew and give rise to all the cells of the blood and the immune system. As they differentiate, HSCs progressively lose their self-renewal capacity and generate lineage-restricted multipotential progenitor cells that in turn give rise to mature cells.
What are hematopoietic stem cells NCBI?
Hematopoietic stem cells (HSCs) are multipotent precursors that have self-renewal capacity and the ability to regenerate all of the different cell types that comprise the blood-forming system (Bonnet, 2002; McCulloch and Till, 2005).
Is Cre endogenous?
Cre recombinase is a widely used tool in the field of molecular biology. The enzyme’s unique and specific recombination system is exploited to manipulate genes and chromosomes in a huge range of research, such as gene knock out or knock in studies….
| Cre recombinase | |
|---|---|
| Chromosome | genome: 0 – 0 Mb |
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What Cre means?
CRE stands for carbapenem-resistant Enterobacterales. Enterobacterales are an order of bacteria commonly found in people’s gastrointestinal tract that can cause infections both in healthcare and community settings.
What type of tissue is hematopoietic?
Hematopoietic and Lymphoid Tissues The hematopoietic tissues arise from hematopoietic stem cells (HSCs) (Fig. 19.1), and include bone marrow, peripheral blood, and certain lymphoid tissue.