What does thymidylate synthase do?
Thymidylate synthase plays a central role in the biosynthesis of thymidylate, an essential precursor for DNA biosynthesis. In addition to its role in catalysis and cellular metabolism, studies from our laboratory have shown that thymidylate synthase functions as an RNA binding protein.
What is the thymidylate synthase gene?
TYMS (Thymidylate Synthetase) is a Protein Coding gene. Diseases associated with TYMS include Rectum Cancer and Mucositis. Among its related pathways are Metabolism and Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics.
What is the product of thymidylate synthase?
deoxythymidine-5-monophosphate
Thymidylate synthase (TS, TYMS) catalyzes the intracellular transfer of a methyl group to deoxyuridine-5-monophosphate (dUMP) to form deoxythymidine-5-monophosphate (dTMP), which is anabolized in cells to the triphosphate (dTTP).
What is thymidylate synthesis?
Thymidylate synthase (TS) (EC 2.1. 1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). Thymidine is one of the nucleotides in DNA. With inhibition of TS, an imbalance of deoxynucleotides and increased levels of dUMP arise. Both cause DNA damage.
Why is the inhibition of thymidylate synthase important?
Thymidylate synthase inhibitors are chemical agents which inhibit the enzyme thymidylate synthase and have potential as an anticancer chemotherapy. This inhibition prevents the methylation of C5 of deoxyuridine monophosphate (dUMP) thereby inhibiting the synthesis of deoxythymidine monophosphate (dTMP).
What enzyme does 5 fluorouracil inhibit?
The fluoropyrimidine 5-fluorouracil (5-FU) is an antimetabolite drug that is widely used for the treatment of cancer, particularly for colorectal cancer. 5-FU exerts its anticancer effects through inhibition of thymidylate synthase (TS) and incorporation of its metabolites into RNA and DNA.
What should patients using 5 FU expect with treatment?
5FU can cause a rash, which may be itchy. During treatment and for several months afterwards, you will be more sensitive to the sun and your skin may burn more easily than usual. You can still go out in the sun, but: use a suncream with a sun protection factor (SPF) of at least 30.
Is thymidylate synthase an enzyme?
Abstract. Thymidylate synthase (TS) is a key enzyme in the synthesis of 2′-deoxythymidine-5′-monophosphate, an essential precursor for DNA biosynthesis. For this reason, this enzyme is a critical target in cancer chemotherapy.
Which anticancer drugs inhibit thymidylate synthase?
Raltitrexed is a specific inhibitor of thymidylate synthase. It is used to treat colorectal cancers.
What should patients using 5FU expect with treatment?
What is 5 fluorouracil used for?
A drug given as an injection to treat cancers of the breast, colon, rectum, stomach, and pancreas and as a cream to treat actinic keratosis (a skin condition that may become cancer) and certain types of basal cell skin cancer.